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Answer for the clue "A congenital disorder caused by having an extra 21st chromosome ", 12 letters:
mongolianism

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Word definitions for mongolianism in dictionaries

WordNet Word definitions in WordNet
n. a congenital disorder caused by having an extra 21st chromosome; results in a flat face and short stature and mental retardation [syn: mongolism , Down's syndrome , Down syndrome , trisomy 21 ]