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Answer for the clue "A region of south central Italy ", 6 letters:
molise

Word definitions for molise in dictionaries

Wikipedia Word definitions in Wikipedia
Molise (; ) is a region of Southern Italy . Until 1963, it formed part of the region of Abruzzi e Molise , alongside the region of Abruzzo . The split, which did not become effective until 1970, makes Molise the youngest region in Italy. The region covers ...