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Answer for the clue "The act of minimizing something ", 12 letters:
minimisation

Word definitions for minimisation in dictionaries

WordNet Word definitions in WordNet
n. the act of reducing something to the least possible amount or degree or position [syn: minimization ] [ant: maximization ]

Wikipedia Word definitions in Wikipedia
Minimisation is a method of adaptive stratified sampling that is used in clinical trials , as described by Pocock and Simon. The aim of minimisation is to minimise the imbalance between the number of patients in each treatment group over a number of factors. ...

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
minimisation \minimisation\ n. minimization. [Chiefly Brit.]

Wiktionary Word definitions in Wiktionary
n. (alternative spelling of minimization English)