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Answer for the clue "Change in the structure of rock by natural agencies such as pressure or heat of introduction of new chemical substances ", 12 letters:
metamorphism

Word definitions for metamorphism in dictionaries

WordNet Word definitions in WordNet
n. change in the structure of rock by natural agencies such as pressure or heat of introduction of new chemical substances

Wikipedia Word definitions in Wikipedia
Metamorphism , in geology, is the solid state recrystallisation of rocks under environmental forces. Metamorphism may also refer to: Metamorphism (Merzbow album) (2006). Metamorphism (computer science) , a concept similar to a hylomorphism. Metamorphic ...

Wiktionary Word definitions in Wiktionary
n. 1 (context geology English) The process by which rocks are changed into other forms by the application of heat and/or pressure. 2 (context zoology English) The process by which insects development through life stages -- as, for example, those of embryo, ...

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Metamorphism \Met`a*mor"phism\, n. (Geol.) The state or quality of being metamorphic; the process by which the material of rock masses has been more or less recrystallized by heat, pressure, etc., as in the change of sedimentary limestone to marble. --Murchison. ...

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
1837, from metamorphic + -ism .

Usage examples of metamorphism.

In nearby regions of the Massif Central we see even more clearly the workings of intracrustal metamorphism, the anatexis engendered above one or more ascending asthenospheric diapirs.

I exclude, of course, the various mutations, autisms, metamorphisms and madnesses with which the Great Vampires were ever afflicted, if afflicted is the right word.