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Answer for the clue "The middle portion of the brain ", 13 letters:
mesencephalon

Word definitions for mesencephalon in dictionaries

WordNet Word definitions in WordNet
n. the middle portion of the brain [syn: midbrain ]

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Mesencephalon \Mes`en*ceph"a*lon\, n. [NL. See Meso- and Encephalon .] (Anat.) The middle segment of the brain; the midbrain. Sometimes abbreviated to mesen . See Brain .

Wiktionary Word definitions in Wiktionary
n. A part of the brain located rostral to the pons and caudal to the thalamus and the basal ganglia, composed of the tectum (dorsal portion) and the tegmentum (ventral portion).

Usage examples of mesencephalon.

The cerebrum has been completely severed from the mesencephalon and the mesencephalon has been bi­sected and—look, Fred, there’s no thalamoid region.

For reasons of its own, evolution allowed mammalian energy to hold sway, and the recently developed human midbrain or mesencephalon, which had folded over the old diencephalon, could be accurately labeled a mammal brain.