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Answer for the clue "Extreme depression characterized by tearful sadness and irrational fears ", 11 letters:
melancholia

Word definitions for melancholia in dictionaries

Wikipedia Word definitions in Wikipedia
Melancholia is a 2008 Philippine film directed by Lav Diaz . It won the Horizons prize at the 65th Venice International Film Festival .

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
1690s, from Modern Latin melancholia (see melancholy ).

Longman Dictionary of Contemporary English Word definitions in Longman Dictionary of Contemporary English
noun EXAMPLES FROM CORPUS ▪ A burden on even the sunniest temperaments, never mind those suffering from inordinate melancholia . ▪ Avicenna claimed it caused melancholia , and Rhazes cautioned that it inflamed the blood and caused pustules in the mouth. ...

WordNet Word definitions in WordNet
n. extreme depression characterized by tearful sadness and irrational fears

Wiktionary Word definitions in Wiktionary
n. 1 Deep sadness or gloom; melancholy 2 clinical depression, characterised by irrational fears, guilt and apathy

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Melancholia \Mel`an*cho"li*a\, n. [L. See Melancholy .] (Med.) A kind of mental unsoundness characterized by extreme depression of spirits, ill-grounded fears, delusions, and brooding over one particular subject or train of ideas.

Usage examples of melancholia.

Some forms of mania and melancholia do seem to improve, but whether that is because of hot baths and cascarilla or whether they have just run their course, I could not say.

Yet the Old Geister acted not, for his rancor was overcome by melancholia.

Every movement rotting with melancholia, Bannon wagged his arms at his sides in one bitter, languorous shrug.

Melancholia is a recursive, self-replicating structure: it continually generates the very alienation of which it then complains.

Behind her new Saints Louis and Paul there would be not only Science purifying Religion and being purified by it, but hypochondria, melancholia, cowardice, stupidity, cruelty, muckraking curiosity, knowledge without wisdom, and everything that the eternal soul in Nature loathes, instead of the virtues of which St Catherine was the figure head.

The symptoms were prostration, sleeplessness, exhaustion, over-fatigue from mental trouble, overstudy and anxiety, indigestion, dyspepsia, constipation, headache, inability to concentrate the mind, general lassitude, melancholia, backache and pains from the top of my head to the sole of my feet.

This proposal made me roar with laughter, and certainly it was of a nature to excite the hilarity of a sufferer from confirmed melancholia, which I was far from being.

Mason's Melancholia so advanc'd that he is not fully aware of sitting wrapp'd in a Blanket arguing Religion with a Mohawk Warrior with whom he is scarcely upon intimate Terms, "that only the Mightiest God may command, deserve at least the one small, respectful Courtesy, of allowing their Line to cross, without a Mark, your Nations' own Great Path.

The ship was called the Melancholia of Departure, the kind of ironic name Ultras favoured for their craft.

Anxiety, hypochondria, displacency, melancholia, costive, delicate stomachs - the ills of the city merchant increased tenfold.

I suddenly remembered the extraordinary changes the human face can undergo in circular insanity, when it changes from melancholia to elation.

I was learned then in science and philosophy, in the history of religions, in inductive and deductive logic, in liver mantic, in the shape and weight of skulls, in pharmacopeia and metallurgy, in all the useless branches of learning which gives you indigestion and melancholia before your time.

Also the libations, as, a decoction of nightshade for Melancholia, or of Indian hemp for Uranus.

He informs me that they may constantly be seen in energetic action in cases of melancholia, and especially of hypochondria.

At the time of our own Civil War the chief carrier was that sufferer from involutional melancholia, that tormented man from whom knives once had to be hidden, Abraham Lincoln.