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Answer for the clue "An informal term for a state of depression ", 7 letters:
megrims

Word definitions for megrims in dictionaries

WordNet Word definitions in WordNet
n. a state of depression; "he had a bad case of the blues" [syn: blues , blue devils , vapors , vapours ]

Wiktionary Word definitions in Wiktionary
n. 1 (plural of megrim English) 2 Any of various diseases of animals, especially horses. ''(More at megrim.)'' 3 (context usually with "the" English) Depression, low spirits, unhappiness.

Usage examples of megrims.

Like Jonathan Edwards, like David Osgood, he felt his call to be to study-work, and was impatient of the egotisms and spiritual megrims, in listening to which, especially from the younger females of his flock, his colleague had won the hearts of so many of his parishioners.

What did Julia Antonia do to those three boys, between her megrims and her vapors, her disastrous choice of husbands, and her inability to keep a properly Roman household?

But what racking pains, on the other hand, arise from gouts, gravels, megrims, toothaches, rheumatisms, where the injury to the animal machinery is either small or incurable?