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Answer for the clue "A state of abnormal softening of tissue ", 7 letters:
malacia

Word definitions for malacia in dictionaries

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
from Latin malacia "a calm at sea," from Greek malakia "softness, delicacy, effeminacy," from malakos "soft" (see mallet ).

WordNet Word definitions in WordNet
n. a state of abnormal softening of tissue

Wiktionary Word definitions in Wiktionary
n. (context medicine English) An abnormal craving for certain types of food. (from 17th c.)

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Osteomalacia \Os`te*o*ma*la"ci*a\, n. [NL., fr. Gr. 'oste`on bone + ? softness.] (Med.) A disease of the bones, in which they lose their earthy material, and become soft, flexible, and distorted. Also called malacia .

Wikipedia Word definitions in Wikipedia
Malacia is a combining form (especially a suffix ) used in medical terminology to denote an abnormal "softening of the tissues ". Osteomalacia (Rickets) Chondromalacia patellae - degenerative cartilage disease Bronchomalacia Keratomalacia

Usage examples of malacia.

Then the three went out to the Maison Malacia, a restaurant where the check took your hat off, and dined.