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Answer for the clue "Swelling (usually in the legs) caused by lymph accumulating in the tissues ", 10 letters:
lymphedema

Word definitions for lymphedema in dictionaries

Wiktionary Word definitions in Wiktionary
alt. (context medicine English) The swelling of tissue due to retention of fluid in the lymph vessels n. (context medicine English) The swelling of tissue due to retention of fluid in the lymph vessels

Wikipedia Word definitions in Wikipedia
Lymphedema is a condition of localized fluid retention and tissue swelling caused by a compromised lymphatic system , which normally returns interstitial fluid to the thoracic duct , then the bloodstream. The condition can be inherited or can be caused ...

WordNet Word definitions in WordNet
n. swelling (usually in the legs) caused by lymph accumulating in the tissues

Usage examples of lymphedema.

The accompanying illustration shows the condition of the limb of a girl of twenty-one, the subject of lymphedema, five years after the inception of the disease.