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Answer for the clue "An ancient region of west central Italy (southeast of Rome) on the Tyrrhenian Sea ", 5 letters:
lazio

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Wikipedia Word definitions in Wikipedia
Lazio is a region of Italy in which Rome is located. Lazio may also refer to: Eccellenza Lazio , the regional football league S.S. Lazio , a football club based in Rome Giro del Lazio , a bicycle race Rick Lazio , a U.S. Representative from the state of ...