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Answer for the clue "An ancient region of west central Italy (southeast of Rome) on the Tyrrhenian Sea ", 5 letters:
lazio

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Lazio (, ; ; ) is one of the 20 administrative regions of Italy , situated in the central peninsular section of the country. With almost 5.9 million residents and a GDP of more than 170 billion euros, Lazio is the second most populated region of Italy (being ...