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Answer for the clue "The activity of giving vitality and vigour to something ", 12 letters:
invigoration

Word definitions for invigoration in dictionaries

Wiktionary Word definitions in Wiktionary
n. The act of invigorate or the state of being invigorated.

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
1660s, noun of action from invigorate .

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Invigoration \In*vig`or*a"tion\, n. The act of invigorating, or the state of being invigorated.

WordNet Word definitions in WordNet
n. quality of being active or spirited or alive and vigorous [syn: animation , spiritedness , brio , vivification ] the activity of giving vitality and vigour to something [syn: vivification , animation ]

Usage examples of invigoration.

To save the nation, that collection of connivers and nonentities around Lincoln needed the invigoration of a man with organizational genius, unparalleled stamina, and a willingness to use power.