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Answer for the clue "The folding in of an outer layer so as to form a pocket in the surface ", 12 letters:
invagination

Word definitions for invagination in dictionaries

Wikipedia Word definitions in Wikipedia
Invagination is the infolding of one part within another part of a structure, a folding that creates a pocket. The term, originally used in embryology , has been adopted in other disciplines as well.

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Invagination \In*vag`i*na"tion\, n. [L. pref. in- + vagina sheath.] (Biol.) The condition of an invaginated organ or part. The inward movement of the wall of a tissue or cell, to form a cavity; also, the cavity thus formed. Specifically: (Biol., Embryology) ...

Wiktionary Word definitions in Wiktionary
n. 1 (context medicine English) The process where an anatomical part invaginates upon itself or into another structure. 2 One of the methods by which the various germinal layers of the ovum are differentiated.

WordNet Word definitions in WordNet
n. the condition of being folded inward or sheathed [syn: introversion ] the folding in of an outer layer so as to form a pocket in the surface; "the invagination of the blastula" [syn: introversion , intussusception , infolding ]

Usage examples of invagination.

After suffering from invagination of the bowel and inflammation of the ovarian tissue, an ovary was discharged through an opening in the sigmoid flexure, and thence expelled from the anus.

Martin had noticed that the feelers fit into rear invaginations when the cords locked together.