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Answer for the clue "A substance (a virus or toxin or immune serum) that is introduced into the body to produce or increase immunity to a particular disease ", 8 letters:
inoculum

Word definitions for inoculum in dictionaries

Wiktionary Word definitions in Wiktionary
n. The active material used in an inoculation; an inoculant

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Inoculum \In*oc"u*lum\, n. (Microbiology) The preparation of microorganisms which is inoculated[5] into a growth medium; as, a small inoculum may not work well for the production phase of a fermentation.

WordNet Word definitions in WordNet
n. a substance (a virus or toxin or immune serum) that is introduced into the body to produce or increase immunity to a particular disease [syn: inoculant ] [also: inocula (pl)]

Usage examples of inoculum.

The inoculum was the secret that the surgeon discovered and passed on to me.