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Answer for the clue "A lack of efficacy ", 17 letters:
inefficaciousness

Word definitions for inefficaciousness in dictionaries

WordNet Word definitions in WordNet
n. a lack of efficacy [syn: inefficacy ] [ant: efficacy ]

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Inefficaciousness \In*ef`fi*ca"cious*ness\, n. Lack of effect, or of power to produce the effect; inefficacy.

Usage examples of inefficaciousness.

Although nobody really appreciated stink lines, for instance, signaling the inefficaciousness of their underarm deodorant, they could live with such indignities, since everyone else was subject to the same automatic insults.