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Answer for the clue "Any pathological hardening or thickening of tissue ", 10 letters:
induration

Word definitions for induration in dictionaries

WordNet Word definitions in WordNet
n. any pathological hardening or thickening of tissue [syn: sclerosis ]

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
late 14c., from Old French induracion "hardness, obstinacy" (14c.) or directly from Medieval Latin indurationem (nominative induratio ) "hardness (especially of the heart)," noun of action from indurare (see endure ).

Wiktionary Word definitions in Wiktionary
n. 1 hardness. 2 Process of becoming hard. 3 (context medical English) Hardening of an area of the body as a reaction to inflammation, hyperemia, or neoplastic infiltration. 4 (context medical English) An area or part of the body that has undergone such ...

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Induration \In`du*ra"tion\, n. [Cf. F. induration, L. induratio hardness of heart.] The act of hardening, or the process of growing hard. State of being indurated, or of having become hard. Hardness of character, manner, sensibility, etc.; obduracy; stiffness; ...