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Answer for the clue "Tireless determination ", 16 letters:
indefatigability

Word definitions for indefatigability in dictionaries

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Indefatigability \In`de*fat`i*ga*bil"i*ty\ ([i^]n`d[-e]*f[a^]t`[i^]*g[.a]*b[i^]l"[i^]*t[y^]), n. The state of being indefatigable.

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
1630s, from indefatigable + -ity .

WordNet Word definitions in WordNet
n. tireless determination [syn: indefatigableness , tirelessness ]

Wiktionary Word definitions in Wiktionary
n. tirelessness; persistence; stamina.

Usage examples of indefatigability.

Scrape away the demons, aliens, vampires, giant spiders, and germs, and you'll find at the core of every King novel a big gooey heart whose golden oldies backbeat preaches the indefatigability of the human spirit, all fleshed out with those trusty characters you've come to know and love: Maine rednecks.

Robots were always racing down the walkways, tidying bedrooms, cleaning lavatories, polishing away madly with all the mindless indefatigability of steel cretins.

Certainly the barbarian's famous indefatigability was absent: Orlando was dripping with virtual sweat and exhausted by very real aches in every joint and muscle.