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Answer for the clue "Unusual lack of skin color ", 16 letters:
hypopigmentation

Word definitions for hypopigmentation in dictionaries

Wiktionary Word definitions in Wiktionary
n. An abnormally reduced pigmentation

Wikipedia Word definitions in Wikipedia
Hypopigmentation is the loss of skin color. It is caused by melanocyte or melanin depletion, or a decrease in the amino acid tyrosine , which is used by melanocytes to make melanin.

WordNet Word definitions in WordNet
n. unusual lack of skin color [ant: hyperpigmentation ]