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Answer for the clue "Extremely high fever (especially in children) ", 12 letters:
hyperpyrexia

Word definitions for hyperpyrexia in dictionaries

WordNet Word definitions in WordNet
n. extremely high fever (especially in children)

Wiktionary Word definitions in Wiktionary
n. (context medicine English) An excessive and unusual elevation of set body temperature greater than or equal to 41°C (105.8°F), or extremely high fever.

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Hyperpyrexia \Hy`per*py*rex"i*a\, n. [NL. See Hyper- , and Pyrexia .] (Med.) A condition of excessive fever; an elevation of temperature in a disease, in excess of the limit usually observed in that disease.