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Answer for the clue "Unusual darkening of the skin ", 17 letters:
hyperpigmentation

Word definitions for hyperpigmentation in dictionaries

Wikipedia Word definitions in Wikipedia
Hyperpigmentation is the darkening of an area of skin or nails caused by increased melanin .

Wiktionary Word definitions in Wiktionary
n. The darkening of an area of skin or nails, caused by increased melanin.

WordNet Word definitions in WordNet
n. unusual darkening of the skin [ant: hypopigmentation ]

Usage examples of hyperpigmentation.

Anyway, basically, what a lab is going to be looking for is whether that hyperpigmentation is intracellular, as in melanocytes, which are the dark, pigmented cells that are much more concentrated in non-Caucasians, or intercellular.