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Answer for the clue "Unusual darkening of the skin ", 17 letters:
hyperpigmentation

Word definitions for hyperpigmentation in dictionaries

WordNet Word definitions in WordNet
n. unusual darkening of the skin [ant: hypopigmentation ]

Wiktionary Word definitions in Wiktionary
n. The darkening of an area of skin or nails, caused by increased melanin.

Wikipedia Word definitions in Wikipedia
Hyperpigmentation is the darkening of an area of skin or nails caused by increased melanin .

Usage examples of hyperpigmentation.

Anyway, basically, what a lab is going to be looking for is whether that hyperpigmentation is intracellular, as in melanocytes, which are the dark, pigmented cells that are much more concentrated in non-Caucasians, or intercellular.