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Answer for the clue "A very prickly woody vine of the eastern United States growing in tangled masses having tough round stems with shiny leathery leaves and small greenish flowers followed by clusters of inedible shiny black berries ", 10 letters:
horsebrier

Word definitions for horsebrier in dictionaries

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
horsebrier \horsebrier\ n. a very prickly woody vine ( Smilax rotundifolia ) of eastern U. S. growing in tangled masses having tough round stems with shiny leathery leaves and small greenish flowers followed by clusters of inedible shiny black berries. ...