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Answer for the clue "The despair you feel when you have abandoned hope of comfort or success ", 12 letters:
hopelessness

Word definitions for hopelessness in dictionaries

WordNet Word definitions in WordNet
n. the despair you feel when you have abandoned hope of comfort or success [ant: hopefulness ]

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Hopeless \Hope"less\, a. Destitute of hope; having no expectation of good; despairing. I am a woman, friendless, hopeless. --Shak. Giving no ground of hope; promising nothing desirable; desperate; as, a hopeless cause. The hopelessword of ``never to return'' ...

Wiktionary Word definitions in Wiktionary
n. the lack of hope; despair

Wikipedia Word definitions in Wikipedia
Hopelessness (stylized as HOPELESSNESS ) is the debut solo album from Anohni (formerly known as Antony Hegarty, the lead singer of Antony and the Johnsons ). It was released on 6 May 2016 on Secretly Canadian , Rough Trade , and Hostess . It features co- ...

Usage examples of hopelessness.

A final sigh of hopelessness came from the Lady Auklet as she moved out of sight up the serpentine steps.

Occasionally, as the afternoon waned beyond the portals of the aviary and she would be required to return to the Sanctuary, he would begin thinking of the hopelessness of the situation and a chill would work its way into the base of his spine and crawl upwards along his back like a spider.

Meanwhile Cressida, among the Greeks, was bewailing the refusal of her father to let her return, the certainty that her lover would think her false, and the hopelessness of any attempt to steal away by night.

Those present obeyed him in silence and Nisa gave the biologist a smile, triumphant, despite the hopelessness of the moment.

He felt the hopelessness of this idiocy, and then Mendora called them forward.

Loss of property, hopelessness as to his future prospects, the inoccupation to which poverty condemned him, combined to reduce him to a state bordering on insanity.

A coldness that was not of isobars and pressure fronts congealed within her gut, a ball of frozen jelly heavy as hopelessness.

And in order to escape from the lovesick girl who has in the meantime transferred all the contents of her closets into your apartment, you flee across the ocean, where you die in hopelessness and misery.

An outwearied hopelessness expressed a passive sentiment very like indifference in the clear wide gaze.

One of the blacks opened the door of the prison with a huge key, we walked in, the door closed behind us, the lock grated, and with the sound there swept over me again that terrible feeling of hopelessness that I had felt in the Chamber of Mystery in the Golden Cliffs beneath the gardens of the Holy Therns.

The loneliness of my position, the hopelessness of my venture, welled up in my heart after that good comradeship, and when the hut was out of sight I went forward down the green grass road, chin on chest, for twenty minutes in the deepest dejection.

She whispered the word urgently, and it pushed back against the despair and the hopelessness that had closed in about her in steadily deepening layers since the march east from the Chard Rush had begun.

Philip never confessed it, but he had settled for the bleak comfort of hopelessness the moment the voice of a WMTG newsreader coming from the portable radio on his desk had distracted his attention from an elaborate doodle with the announcement that a third name had been definitively added to that of Shane Auslander and Trey Wilk.

When the last of the Warriors had launched from the bay, Starbuck gazed out through the launch aperture at the laser blasts flashing back and forth between Cylon Raiders and Colonial Vipers and felt a terrible hopelessness overcome him.

Consequently the Caesarians no longer mourned such as were perishing but counted them fortunate to escape from further torment, and in their hopelessness wished that they, too, were among those already dead, wounded were far more in number than those died, and being struck from a distance with stones and javelins and receiving no blow from near at hand their wounds were in many places, and not as a rule favorably located.