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Answer for the clue "Feeling downcast and disheartened and hopeless ", 13 letters:
heartsickness

Word definitions for heartsickness in dictionaries

WordNet Word definitions in WordNet
n. feeling downcast and disheartened and hopeless [syn: despondency , despondence , disconsolateness ]

Wiktionary Word definitions in Wiktionary
n. The condition of being heartsick

Usage examples of heartsickness.

For the love of God, Sister, put aside the fear and heartsickness that have robbed you of your good sense and integrity, and act like a queen!