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Answer for the clue "Serious weakening and loss of energy ", 12 letters:
enfeeblement

Word definitions for enfeeblement in dictionaries

WordNet Word definitions in WordNet
n. serious weakening and loss of energy [syn: debilitation , enervation , exhaustion ]

Wiktionary Word definitions in Wiktionary
n. The act of enfeeble; debilitation, enervation or devitalization

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Enfeeblement \En*fee"ble*ment\, n. The act of weakening; enervation; weakness.

Usage examples of enfeeblement.

In like manner there is a tendency to premature enfeeblement, for the earlier the system matures, the sooner it deteriorates.

Bourrienne had nourished for his disgrace, the enfeeblement of his faculties, and the poverty he was reduced to, rendered him accessible to the pecuniary offers made to him.

Influenza, cholera, and at last maculated fever, the progressive enfeeblement of economic life and new developments of human relationship, prevented that Conference from ever meeting.

There are colostomy bags and projectile vomiting and cirrhotic discharges and missing limbs and misshapen heads and incontinence and Kaposi's Sarcoma and suppurating sores and all different levels of enfeeblement and impulse-control-deficit and damage.

Would this not weaken their blood as well, cause all manner of deformities, enfeeblements not only of the body but also of the mind?