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Answer for the clue "Large genus of low-growing shrubby ribbed cacti of Mexico and southwestern United States ", 12 letters:
echinocereus

Word definitions for echinocereus in dictionaries

Wikipedia Word definitions in Wikipedia
Echinocereus is a genus of ribbed, usually small to medium-sized cylindrical cacti , comprising about 70 species native to the southern United States and Mexico in very sunny rocky places. Usually the flowers are large and the fruit edible. The name comes ...