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Answer for the clue "Antihistamine (trade name Benadryl) used to treat allergic reactions involving the nasal passages (hay fever) and also to treat motion sickness ", 15 letters:
diphenhydramine

Word definitions for diphenhydramine in dictionaries

WordNet Word definitions in WordNet
n. antihistamine (trade name Benadryl) used to treat allergic reactions involving the nasal passages (hay fever) and also to treat motion sickness [syn: Benadryl ]

Wikipedia Word definitions in Wikipedia
Diphenhydramine ( DPH , DHM ) is a first-generation antihistamine mainly used to treat allergies . It is also used in the management of drug-induced parkinsonism and other extrapyramidal symptoms . The medication has a sedating effect and is FDA-approved ...

Wiktionary Word definitions in Wiktionary
n. An antihistamine and sedative drug that blocks the effect of histamine at H1 receptor sites, reducing smooth muscle contraction.

Usage examples of diphenhydramine.

The combination of diphenhydramine and Valium caused you to go into a deep sleep.