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Answer for the clue "The act of reducing the vitality of something ", 14 letters:
devitalization

Word definitions for devitalization in dictionaries

Wiktionary Word definitions in Wiktionary
n. The act of devitalize.

WordNet Word definitions in WordNet
n. the act of reducing the vitality of something [syn: devitalisation ]

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Devitalize \De*vi"tal*ize\, v. t. To deprive of life or vitality. -- De*vi`tal*i*za"tion , n.