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Answer for the clue "Abnormal loss of mineral salts (especially from bone) ", 16 letters:
demineralization

Word definitions for demineralization in dictionaries

WordNet Word definitions in WordNet
n. abnormal loss of mineral salts (especially from bone) [syn: demineralisation ] the removal of minerals and mineral salts from a liquid (especially from water) [syn: demineralisation ]

Wiktionary Word definitions in Wiktionary
n. 1 (context chemistry English) The chemical engineering process in which mineral salts are removed from a liquid. 2 (context medicine English) The loss of minerals, especially those of calcium, from bone.

Wikipedia Word definitions in Wikipedia
Demineralization - it is the opposite process of mineralization , a process to reduce the content of mineral substances in tissue or organism, such as bone demineralization, of teeth. Demineralization can lead to serious diseases such as osteoporosis or ...

Usage examples of demineralization.

Spring-loaded straps pulled the walker toward the tread surface, against which his or her feet pushed, for an hour or more a day by prescription, an exercise designed to slow, if not stop, the lower body deconditioning and long bone demineralization of free fall dwellers.

Spring-loaded straps pulled the walker toward the tread surface, against which his or her feet pushed, for an hour or more a day by prescription, an exercise designed to slow, if not stop, the lower body deconditioning and long bone demineralization of free fell dwellers.

That, coupled with the severe muscle atrophy, heel bone demineralization, and decrease in heart function, laid them low, opened up their immune system to attack.