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Answer for the clue "Abnormal loss of mineral salts (especially from bone) ", 16 letters:
demineralisation

Word definitions for demineralisation in dictionaries

Wiktionary Word definitions in Wiktionary
n. (alternative spelling of demineralization English)

Wikipedia Word definitions in Wikipedia
Demineralization (physiology) Bone demineralisation leading to osteoporosis Tooth demineralisation that leads to dental caries Demineralizing of silk worm cocoons Desalination Also

WordNet Word definitions in WordNet
n. abnormal loss of mineral salts (especially from bone) [syn: demineralization ] the removal of minerals and mineral salts from a liquid (especially from water) [syn: demineralization ]