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Answer for the clue "A developmental abnormality in which there is only one eye ", 8 letters:
cyclopia

Word definitions for cyclopia in dictionaries

Wikipedia Word definitions in Wikipedia
Cyclopia (also cyclocephaly or synophthalmia ) is a rare form of holoprosencephaly and is a congenital disorder (birth defect) characterized by the failure of the embryonic prosencephalon to properly divide the orbits of the eye into two cavities. Its incidence ...

WordNet Word definitions in WordNet
n. a developmental abnormality in which there is only one eye

Wiktionary Word definitions in Wiktionary
n. (context medicine English) A congenital abnormality in which the orbits of the eye do not divide to form separate sockets

Usage examples of cyclopia.

For instance, lithium salts easily induced cyclopia, a single central eye, in fish embryos.