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Answer for the clue "The act of coagulating blood and destroying tissue with a hot iron or caustic agent or by freezing ", 13 letters:
cauterization

Word definitions for cauterization in dictionaries

Wikipedia Word definitions in Wikipedia
The medical practice or technique of cauterization (or cauterisation, or cautery) is the burning of part of a body to remove or close off a part of it, which destroys some tissue in an attempt to mitigate bleeding and damage, remove an undesired growth, ...

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Cauterization \Cau`ter*i*za"tion\, n. [Cf. F. caut[`e]risation.] (Med.) The act of searing some morbid part by the application of a cautery or caustic; also, the effect of such application.

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
c.1400, from Old French cauterisation (14c.) and directly from Late Latin cauterizationem (nominative cauterizatio ), noun of action from past participle stem of cauterizare (see cauterize ).

WordNet Word definitions in WordNet
n. the act of coagulating blood and destroying tissue with a hot iron or caustic agent or by freezing [syn: cautery , cauterisation ]

Wiktionary Word definitions in Wiktionary
n. The act of searing some morbid part by the application of a cautery or caustic; also, the effect of such application.

Usage examples of cauterization.

However, the idea did not occur to me immediately, and the cauterization could not have been delayed Every second counts with such injuries.

No vital organs punctured, appears to be complete cauterization at point-of-entry, but they're still both dead.

High voltage would explain the instant cauterization and lack of bleeding.

They had no contact on any of their military wavelengths, Bisesa’s phone muttered about its continuing cauterization, no SAR teams came flapping out of the UN base in response to their patiently bleeping beacons—there was no medevac for Casey.

The ancient machines were directed to a new objective: to the elimination of waste—to cauterization, if necessary.

In any case, incising an FROB’s ultratough tegument required the tools of an engineering workshop rather than an operating theater, because the cauterization effects of using fine laser cutters, which were so necessary during internal surgery, seriously inhibited healing along the faces of tegument incisions.