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Answer for the clue "An abnormal enlargement of the heart ", 12 letters:
cardiomegaly

Word definitions for cardiomegaly in dictionaries

Wikipedia Word definitions in Wikipedia
Cardiomegaly is a medical condition in which the heart is enlarged. It is more commonly referred to as an enlarged heart. The causes of cardiomegaly may vary. Many times this condition results from high blood pressure ( hypertension ) or coronary artery ...

WordNet Word definitions in WordNet
n. an abnormal enlargement of the heart; "mild cardiomegaly is common in athletes" [syn: megalocardia , megacardia , enlarged heart ]

Wiktionary Word definitions in Wiktionary
n. megalocardia

Usage examples of cardiomegaly.

At the VA hospital in Little Rock, he was diagnosed with cardiomegaly, an enlargement and deterioration of the heart muscle.