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Answer for the clue "Any general reduction in vitality and strength of body and mind resulting from a debilitating chronic disease ", 8 letters:
cachexia

Word definitions for cachexia in dictionaries

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
"bad general state of health," 1540s, from Latinized form of Greek kakhexia "bad habits," from kakos "bad" (see caco- ) + -exia , related to exis "habit or state," from exein "to have, be in a condition," from PIE root *segh- "to hold, hold in one's power, ...

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Cachexia \Ca*chex"i*a\, Cachexy \Ca*chex"y\, n. [L. cachexia, Gr. kachexi`a; kako`s bad + "e`xis condition.] A condition of ill health and impairment of nutrition due to impoverishment of the blood, esp. when caused by a specific morbid process (as cancer ...

WordNet Word definitions in WordNet
n : any general reduction in vitality and strength of body and mind resulting from a debilitating chronic disease [syn: cachexy , wasting ]

Wiktionary Word definitions in Wiktionary
n. (context medicine pathology English) A systemic wasting of muscle tissue, with or without loss of fat mass, that accompanies a chronic disease.

Wikipedia Word definitions in Wikipedia
Cachexia (from Greek κακός kakos "bad" and ἕξις hexis "condition") or wasting syndrome is loss of weight , muscle atrophy , fatigue, weakness, and significant loss of appetite in someone who is not actively trying to lose weight. The formal definition of ...

Usage examples of cachexia.

There are eminent physicians who swear that it is no more effective than strong tea, and there are those who swear that it is effective in treating anemia, cachexia, scrofula, gastrointestinal catarrh, and malfunctions of the lungs, kidneys, liver, heart, and genital organs.

The wagon they traveled in was loaded with fancy little colored bottles of medicine, each with its special disease to cure: cancer, consumption, neuralgia, malaria, cachexia, stroke, fit, and seizure.

In other cases, as you very justly observed, there seems to be a very marked cachexia associated with the exhibition of the spirit in question, even in comparatively small doses.