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Answer for the clue "English actor who was the first to play the leading role in several of Shakespeare's tragedies (1567-1619) ", 7 letters:
burbage

Word definitions for burbage in dictionaries

Wikipedia Word definitions in Wikipedia
Burbage is a surname. Notable people with the surname include: James Burbage (1531–1597), father of the Burbage brothers and builder of 'The Theatre' Richard Burbage (1567–1619), actor in William Shakespeare's theater company Cuthbert Burbage (1566–1636), ...