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Answer for the clue "An abnormal condition in which a normal opening or tube in the body (as the urethra) is closed or absent ", 7 letters:
atresia

Word definitions for atresia in dictionaries

Wiktionary Word definitions in Wiktionary
n. (context pathology English) A condition in which a body orifice or passage in the body is abnormally closed or absent.

Wikipedia Word definitions in Wikipedia
Atresia is a condition in which an orifice or passage in the body is (usually abnormally) closed or absent. Examples of atresia include: Imperforate anus , malformation of the opening between the rectum and anus. Microtia , absence of the ear canal or failure ...

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Atresia \A*tre"si*a\, n. [NL., fr. Gr. ? not perforated.] (Med.) Absence or closure of a natural passage or channel of the body; imperforation.

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
"occlusion of a natural passage in the body," 1807, from Modern Latin atresia , from Greek atretos "not perforated," from a- , privative prefix, + tresis "perforation," from PIE *tere- (1) "to rub, turn," with derivatives referring to boring and drilling ...

WordNet Word definitions in WordNet
n. an abnormal condition in which a normal opening or tube in the body (as the urethra) is closed or absent

Usage examples of atresia.

The commonly associated defects are: More or less completely septate bladder, atresia ani, or more rarely double anus, double urethra, increased breadth of the bony pelvis with defect of the symphysis pubis, and possibly duplication of the lower end of the spine, and hernia of some of the abdominal contents into a perineal pouch.

Cayley, Smith, Sourrouille, and Stankiewiez of Warsaw discuss atresia of the mouth.

Anorectal atresia is the ordinary imperforation of the anus, in which the rectum terminates in the middle of the sacral cavity.

Hulke reports a case of congenital atresia of the vagina in a brunette of twenty, menstruation occurring through the urethra.

He also mentions the instance of congenital atresia of the vagina with hernia of both ovaries into the left groin in a servant of twenty, and the case of an imperforate vagina in a girl of nineteen with an undeveloped uterus.

Arand mentions recovery after atresia of the anus with passage of excrement from the vulva.

Lacerations of the urethra from urethral coitus in instances of vaginal atresia or imperforate hymen may also excite serious hemorrhage.

When I was working in pediatrics, we had a little girl who had biliary atresia, which is usually a fatal-type thing.