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Answer for the clue "A substance that relieves or prevents itching ", 12 letters:
antipruritic

Word definitions for antipruritic in dictionaries

WordNet Word definitions in WordNet
n. a substance that relieves or prevents itching

Wikipedia Word definitions in Wikipedia
Antipruritics , also known as anti-itch drugs , are medications that inhibit the itching (Latin: pruritus ) often associated with sunburns , allergic reactions , eczema , psoriasis , chickenpox , fungal infections , insect bites and stings like those from ...

Wiktionary Word definitions in Wiktionary
n. a medical agent that stops itching.

Usage examples of antipruritic.

Popeye loved it when every few weeks her owner would put her in a sink of warm water and lather her up with Nusalt antiseborrheic therapeutic shampoo, followed by the Relief antipruritic oatmeal and pramoxine cream rinse that her owner kneaded into Popeye's fur for exactly seven minutes, as the directions prescribed.