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Answer for the clue "An anagram that means the opposite of the original word or phrase ", 8 letters:
antigram

Word definitions for antigram in dictionaries

Wiktionary Word definitions in Wiktionary
n. One of a pair of anagrams with opposite meanings.

WordNet Word definitions in WordNet
n. an anagram that means the opposite of the original word or phrase; "`restful' is the antigram of `fluster'"