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Answer for the clue "A defect in brain development resulting in small or missing brain hemispheres ", 11 letters:
anencephaly

Word definitions for anencephaly in dictionaries

Wiktionary Word definitions in Wiktionary
n. A lethal birth defect in which most of the brain and parts of the skull are missing; absence of the encephalon.

Wikipedia Word definitions in Wikipedia
Anencephaly is the absence of a major portion of the brain , skull , and scalp that occurs during embryonic development . It is a cephalic disorder that results from a neural tube defect that occurs when the rostral (head) end of the neural tube fails to ...

WordNet Word definitions in WordNet
n. a defect in brain development resulting in small or missing brain hemispheres [syn: anencephalia ]

Usage examples of anencephaly.

But by then she was almost grateful, having learned along the way about cretinism, microcephalia, PKU, anencephaly, spina bifida.

Angell and Elsner in March, 1895, reported a case of anencephaly, or rather pseudencephaly, associated with double divergent strabismus and limbs in a state of constant spastic contraction.

Geoffroy-Saint-Hilaire cites an example of anencephaly which lived a quarter of an hour.