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Answer for the clue "A defect in brain development resulting in small or missing brain hemispheres ", 11 letters:
anencephaly

Word definitions for anencephaly in dictionaries

WordNet Word definitions in WordNet
n. a defect in brain development resulting in small or missing brain hemispheres [syn: anencephalia ]

Wikipedia Word definitions in Wikipedia
Anencephaly is the absence of a major portion of the brain , skull , and scalp that occurs during embryonic development . It is a cephalic disorder that results from a neural tube defect that occurs when the rostral (head) end of the neural tube fails to ...

Wiktionary Word definitions in Wiktionary
n. A lethal birth defect in which most of the brain and parts of the skull are missing; absence of the encephalon.

Usage examples of anencephaly.

But by then she was almost grateful, having learned along the way about cretinism, microcephalia, PKU, anencephaly, spina bifida.

Angell and Elsner in March, 1895, reported a case of anencephaly, or rather pseudencephaly, associated with double divergent strabismus and limbs in a state of constant spastic contraction.

Geoffroy-Saint-Hilaire cites an example of anencephaly which lived a quarter of an hour.