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Answer for the clue "Macedonian city with Greek and Roman ruins ", 6 letters:
edessa

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Wikipedia Word definitions in Wikipedia
Edessa is the historical name of a city in Mesopotamia, now Şanlıurfa , Turkey. Edessa may also refer to: Edessa (genus) , a large genus of stink bugs Edessa, Greece County of Edessa , a crusader state Osroene , an ancient kingdom and province of the Roman ...