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Answer for the clue ""You're ___!" (Archie Bunker comment) ", 4 letters:
apip

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Wikipedia Word definitions in Wikipedia
APAF1-interacting protein is a protein that in humans is encoded by the APIP gene . It is an enzyme with Methylthioribulose 1-phosphate dehydratase activity which is involved in the methionine salvage pathway. APIP deficiency is associated with cell death ...