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Answer for the clue "Get-up-and-go ", 5 letters:
oomph

Alternative clues for the word oomph

Word definitions for oomph in dictionaries

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
"sexual attractiveness," 1937, suggestive visceral physical sound. Ann Sheridan (1915–1967) was the original Hollywood oomph girl (1939).

Usage examples of oomph.

With the last bit of oomph the Vette had, Ryan drove off the road and into the dense vegetation, hoping to hide the car.

I had oomph enough to vacate the area steps ahead of an unpleasant interview with the goon squad, who did not seem to care if I had legitimate business on the Hill.