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YRC could mean:

  • Yorkshire Ramblers' Club (YRC), a senior mountaineering and caving club based in Yorkshire, England
  • York Railway (reporting mark YRC), a short line railroad operating between York and Hanover, Pennsylvania
  • YRC Worldwide (NASDAQ: YRCW), the combination of Yellow Freight and Roadway Transportation, a Fortune 500 company based in Overland Park, Kansas