The acronym XPG can refer to the following:
- Paris Gare du Nord, railway station, IATA airport code.
- X/Open Portability Guide, which specifies the requirements for any system which is intended to be a Unix system, and a predecessor to the POSIX standard
- Xeroderma pigmentosum, complementation group G, a genetic disorder and a possible source of skin tumors
- an endonuclease involved in nucleotide excision repair