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XOP may refer to:

  • XML-binary Optimized Packaging, a W3C recommendation for embedding binary data in XML
  • External Operations in IGOR Pro, used to add data acquisition, manipulation and analysis features
  • X-ray Oriented Programs, a widget-based driver software that is used as front-end interface optical simulations
  • XOP instruction set, a computer instruction set introduced by AMD in 2009
  • A touhou-like game, but without the Japanese.