XLD may refer to:
- Xylose lysine deoxycholate or XLD agar, a growth medium for bacterial cultures.
- X Lossless Decoder, a tool for Mac OS X that is able to decode, convert, and play various 'lossless' audio files.
- The XLD connector, a keyed variant of the XLR connector.
- A series of Atari computers, including the 1450 XLD.
- A Microsoft Excel file format.