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WHI may refer to:

  • W Holding Company, a failed bank holding company in Puerto Rico whose former NYSE ticker symbol was WHI
  • Walgreens Health Initiatives, a Pharmacy Benefit Management subunit of Walgreens Health Services
  • Waterloo Hydrogeologic Inc., a groundwater software, training and consulting company
  • Women's Health Initiative, a large, longitudinal study of the health of women.
  • Women's Health Issues (journal), an academic journal on women's health