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Wheler is a surname, and may refer to:

  • Humphrey Wheler (fl. 1600), English landowner and politician
  • Sir William Wheler, 1st Baronet (c. 1601–1666), English politician
  • Sir George Wheler (clergyman and scholar) (1650–1723), English clergyman and travel writer
  • Francis Wheler (1656–1694), Royal Navy officer
  • George Wheler (mill owner) (1836–1908), Canadian mill owner and political figure
  • Granville Wheler (1701–1770), English clergyman and natural philosopher