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Wassoulou is a cultural area and historical region in the Wassoulou River Valley of West Africa. It is home to about 160,000 people, and is also the native land of the Wassoulou genre of music.

Wassoulou surrounds the point where the borders of three present-day countries meet: Mali, Côte d'Ivoire, and Guinea. It includes portions of southwestern Mali, northwestern Côte d'Ivoire, and eastern Guinea. It is bordered by the Niger River to the northwest, and by the Sankarani River to the east.

The name Wassoulou is alternately spelled Wassulu, Wassalou, and Ouassalou.