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What is "vest buster"

Wiktionary
vest buster

n. (context idiomatic English) a handgun cartridge that can fully penetrate a contemporary bulletproof vest.

Wikipedia
Vest buster

Vest buster is a handgun cartridge that can fully penetrate a contemporary bulletproof vest.

While several handguns and cartridges could be considered vest busters, two popular examples are the FN Five-seven firing the FN 5.7×28mm and the Smith & Wesson Model 500 firing the .500 S&W Magnum.