VDR may refer to multiple entities:
- V, an archaic abbreviation for "van der"
- vdR, abbreviation for "van der Roest", a family name of Dutch origin
- Verein Deutscher Rosenfreunde, the Union of German Friends of Roses
- Vertical dimension at rest, a mandibular position used in dentistry to estimate vertical dimension of occlusion
- Virginia Declaration of Rights
- Virtual data room
- Vitamin D receptor
- Voltage Dependent Resistor
- Video Disk Recorder, also known as Linux VDR, a software to record and store digital video on a Linux computer
- Voyage Data Recorder, an electronic device on ships that records navigational status for later accident investigation (a type of black box)
- Vehicle Data Recorder, an electronic device in automotive units that records OBDII CAN BUS data.