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VCF may refer to:

  • Vaginal contraceptive film, a type of spermicide birth control
  • Valencia CF, a Spanish football club in La Liga
  • Vapor cloud fire, a deflagration fire
  • Variant Call Format, a standard for storing gene sequence variations
  • vCard, a file format standard for electronic business cards (.vcf)
  • Vertebral compression fracture, a collapse of a vertebra
  • Victory Christian Fellowship, an organization of churches in the Philippines
  • Vietnam Children's Fund
  • Vintage Computer Festival, an annual event in Mountain View, California, and other locations
  • Virtual Case File, a defunct software system developed by the US FBI
  • Visual Component Framework, an open source C++ application framework
  • Voltage-controlled filter, a signal processing device in an analog synthesizer